I am, thanks to my wife, a dedicated follower of Desperate Housewives. I am also a huge fan of Family Guy, which has just been re-premiered across from Desperate Housewives.
I think that placing these two show opposite of each other was actually a great move for FOX, in my mind splitting the male and female audience. Unfortunately Desperate Housewives has earned my loyalty. But that is why God made TiVo.